Endocrine Abstracts

Significant advancements have been made in the last century regarding the neuronal control of feeding behavior and energy expenditure. The effects and mechanism of action of various peripheral metabolic signals on the brain have become clearer. Molecular and genetic tools for visualizing and manipulating individual components of brain homeostatic systems in combination with neuroanatomical, electrophysiological, behavioral and pharmacological techniques have begun to elucidate...

Osteoporosis is a progressive disease characterized by excessive bone loss which is often accompanied by augments in marrow adiposity as a result of estrogen deficiency, metabolic abnormalities or medications. Nuclear receptor estrogen-related receptor alpha (ESRRA) has a demonstrated role in energy homeostasis and fat metabolism. To determine if ESRRA is a potential therapeutic target for regulating fat-bone balance, we generated an adipocyte-specific ESRRA knockout mice (ESR...

A 34-year-old African woman presented with a 4-month history of profound lethargy, weight loss and a 3-day history of vomiting, fever, confusion, and drowsiness. She had given birth to her third child 6 months previously. Her pregnancy and delivery were uncomplicated and she had breastfed for 5 months prior to discontinuing due to exhaustion.Investigations showed severe hypercalcaemia (4.94 mmol/l) and undetectable PTH. Hypercalcaemia was unresponsive to...

Recent studies have reported that tissue micro-environment including tumor infiltrating lymphocytes (TILs) as well as neo-angiogenesis played pivotal roles in biological and clinical behavior of various human malignancies. In adrenal neoplasms, TILs are far more frequently detected in cortical than medullary tumors. In adrenocortical adenomas, we have recently demonstrated that enhanced angiogenic chemokines, especially CXCL12, in cortisol producing adenoma (CPA), induced TILs...

A 6-hour octreotide suppression test (OST) is useful in the selection of patients with acromegaly for chronic somatostatin depot analogues treatment. However, it is time consuming and that brings inconvenience to patients. We aim to simplify the blood sampling of OST, and determine the reliability of a short version of the classic 6-hour OST. The data provided in the supplementary tables of the primary manuscript were used to re-analyze the efficacies of the simplified OST tes...

Objective: The distinction between constitutional delay of growth and puberty (CDGP) and congenital hypogonadotropic hypogonadism (CHH) in males with delayed puberty is difficult but important for timely treatment. We aimed to summarize the sensitivity and specificity of serum inhibin B (INHB) level in distinguishing CHH with CDGPin boys.Methods: Studies in the PubMed, EMBASE and Cochrane Library databases were systematically searched from the date of da...

Background: Diabetes prevalence and mortality are increasing rapidly and glycemic goals (hemoglobin A1c < 7%) are often not achieved in patients with type 2 diabetes in China, The low control rate of diabetes has become a global problem. The management of community diabetes is the most effective choice to prevent and control chronic diseases.Objective: To improve the management of diabetes mellitus in community, we analyze the effect of hospital-comm...

Background: Resection of the adrenal gland is a challenging intervention that requires close endocrinological supervision for the correct assessment of hormones to minimise complications peri-operatively (peri-op) and post-operatively (post-op).Objectives: This study assessed the function of the hypothalamus–pituitary–adrenal axis and the related management according to underlying adrenal disorders.Methods: We reviewed 16...

Objective: Both MODY and GDM are characterized by pancreatic beta cell dysfunction. The study aimed to first investigate the associations between miR-SNPs of HNF4A, HNF1A and HNF1B genes and the GDM susceptibility and lipid profiles.Methods: The software PolymiRTS were used to screen miR-SNPs. Genotyping of SNPs was performed with TaqMan allelic discrimination assays in 839 GDM patients and 900 controls. Multivariable logistic ...

Context: Postoperative central diabetes insipidus (PDI) is one of the most common complications of surgical treatment of pituitary adenoma, temporary or permanant. The diagnosis of PDI was suspicious in some occasions and inappropriate prescription of antidiuretic hormone was harmful. Generally, high level serum uric acid (HUA) was a clue for central diabetes insipidus, but we did not know its role for the brain postoperative subjects. As we know, the food intake and health co...